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All esters have a half-life, so the release of the steroid from the
ester will peak and decline at different times depending on the ester.
Think of it as a sharp increase followed by a sharp decline in blood
serum levels of the steroid being used. This can be a couple of hours or
a couple of days.
Like all steroids, testosterone, on its own, has a very short half-life.
As a result, manufacturers of synthetic testosterone use a chemical
process to attach an ester chain to the testosterone base. The
attachment of the ester chain to the hormone makes it oil soluble, while
slowing the rate at which the steroid leaves the body. As a results,
testosterone cannot attach to the androgen receptors until the ester
chain has been cleaved off from the hormone.
In the end, adding the ester chain makes the steroid more manageable
for dosing because the shot frequency goes down to only a couple of
times per week. This is compared to several daily shots if the base
hormone was being injected. The base hormone, without an ester chain,
will be in and out of the body in only a few hours. This forces the user
to take several daily shot in order to run an effective cycle or TRT
In order to maintain consistency in the release of testosterone from
each injection, the designers of Sustanon 250 used four esters in the
same oil carrier. The intention in mixing four esters is to allow for a
cascading effect, using the different peaks and troughs of the different
ester to keep levels fairly steady. By combining esters of different
lengths, they created a somewhat perfect TRT steroid. The shorter
propionate ester will peak quickly, while the mid-length ones like
phenylpropionate build up, and the shorter-to-mid-length esters decline
sharply; at the same time, the longer decanoate ester is just reaching
its peak release.