Product Name: BETA-NICOTINAMIDE MONONUCLEOTIDE
Synonyms: BETA-NMN;BETA-NICOTINAMIDE MONONUCLEOTIDE;BETA-NICOTINAMIDE
RIBOSE MONOPHOSPHATE;NMN;NICOTINAMIDE-1-IUM-1-BETA-D-RIBOFURANOSIDE
5′-PHOSPHATE;NICOTINAMIDE RIBOTIDE;NICOTINAMIDE
MONONUCLEOTIDE;3-(aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium
CAS: 1094-61-7
MF: C11H15N2O8P
MW: 334.22
EINECS: 214-136-5
Product Categories: Amines;Aromatics;Bases & Related
Reagents;Intermediates & Fine Chemicals;
Derivatives;Nucleotides;Pharmaceuticals
Storage temp. 2-8°C
Chemical Properties : White Solid
Usage A product of the extracellular Nicotinamide
phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate.
It ameliorates glucose intolerance by restoring NAD+ levels in
HFD-induced T2D mice . It also enhances hepatic sensitivity and restores
gene expression related to oxidative stress, inflammatory response, and
circadian rhythm, partly through SIRT1 activation . beta-Nicotinamide mononucleotide powder
β-Nicotinamide mononucleotide Description
Nicotinamide mononucleotide (NMN), a product of the NAMPT reaction
and a key NAD+ intermediate, ameliorates glucose intolerance by
restoring NAD+ levels in HFD-induced T2D mice. NMN also enhances hepatic
sensitivity and restores gene expression related to oxidative stress,
inflammatory response, and circadian rhythm, partly through SIRT1
activation. NMN is used for studying binding motifs within RNA aptamers
and ribozyme activation processes involving β-nicotinamide
mononucleotide (β-NMN)-activated RNA fragments. It is to be used for
research only.
Beta-Nicotinamide Mononucleotide Application
The coenzyme NAD and its derivatives are involved in hundreds of
metabolic redox reactions and are utilized in protein ADP-ribosylation,
histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC
2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the
condensation of nicotinamide mononucleotide (NMN) or nicotinic acid
mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.
NMNAT1 is the most widely expressed of three orthologous genes with
nicotinamide-nucleotide adenylyltransferase (NMNAT) activity.
Genetically engineered mice lacking NMNAT1 die during early
embryogenesis, indicating a critical role of this gene in organismal
viability.[citation needed] In contrast, mice lacking NMNAT2, which is
expressed predominantly in neural tissues, complete development but die
shortly after birth. However, NMNAT1 is dispensable for cell viability,
as homozygous deletion of this gene occurs in glioblastoma tumors and
cell lines. NMNAT enzymatic activity is probably essential at the
cellular level, as complete ablation of NMNAT activity in model
organisms leads to cellular inviability.
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