White needle crystal or crystalline powder, odorless and tasteless.
Almost insoluble in water or dilute hydrochloric acid, soluble in
ethanol or ethyl acetate, soluble in acetone, acetic acid, slightly
soluble in chloroform or ether.β-agonist Powder
Indapamide is an over-the-counter diuretic antihypertensive drug
commonly used in China, which has the advantages of good efficacy,
stable antihypertensive and less side effects.
Indapamide has dual effects of diuresis and calcium antagonism. By
inhibiting Na+ reabsorption at the proximal end of the distal convoluted
tubule, it can produce diuretic effect and block Ca2+ internal flow. It
is highly selective to vascular smooth muscle, so as to dilate
peripheral small blood vessels and generate antihypertensive effect. But
the effect on vascular smooth muscle stronger diuretic effect, below
the diuretic doses can step-down, higher doses showed diuretic effect,
but no thiazide diuretic shortcomings, namely not cause orthostatic
hypotension, flush and reflective tachycardia, on blood picture,
metabolism of blood fat, sugar and renal function also had no obvious
effect, therapeutic doses of heart rate, cardiac output, no significant
changes in electrocardiogram (ecg) were on the central nervous system
and plant nerve has no obvious effect. The antihypertensive effect was
produced by oral administration for 2 ~ 3h and maintained for 24h. The
diuretic effect appeared for 3h and reached the maximum effect for 4 ~
6h. Different from other diuretics, this product has high lipid
solubility. After oral absorption, the plasma concentration of liver and
kidney is the highest, while the concentration of heart, lung, muscle
and fat is lower. This product is mainly excreted from the kidney by
metabolites and 5% prototype. Indapamide is suitable for mild and
moderate primary hypertension, can also be used for congestive heart
failure caused by water sodium retention, with renal failure are also
applicable to the patients with high blood pressure, diabetes,
hyperlipidemia, use antihypertensive effect is remarkable, and beta
blockers used curative effect is better, because this drug has diuretic
effect, can cause hypokalemia, can complement potassium at the same
time.
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