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High Quality 995 API Indapamide Powder 21/10/2019

White needle crystal or crystalline powder, odorless and tasteless. Almost insoluble in water or dilute hydrochloric acid, soluble in ethanol or ethyl acetate, soluble in acetone, acetic acid, slightly soluble in chloroform or ether.β-agonist Powder

Indapamide is an over-the-counter diuretic antihypertensive drug commonly used in China, which has the advantages of good efficacy, stable antihypertensive and less side effects.

Indapamide has dual effects of diuresis and calcium antagonism. By inhibiting Na+ reabsorption at the proximal end of the distal convoluted tubule, it can produce diuretic effect and block Ca2+ internal flow. It is highly selective to vascular smooth muscle, so as to dilate peripheral small blood vessels and generate antihypertensive effect. But the effect on vascular smooth muscle stronger diuretic effect, below the diuretic doses can step-down, higher doses showed diuretic effect, but no thiazide diuretic shortcomings, namely not cause orthostatic hypotension, flush and reflective tachycardia, on blood picture, metabolism of blood fat, sugar and renal function also had no obvious effect, therapeutic doses of heart rate, cardiac output, no significant changes in electrocardiogram (ecg) were on the central nervous system and plant nerve has no obvious effect. The antihypertensive effect was produced by oral administration for 2 ~ 3h and maintained for 24h. The diuretic effect appeared for 3h and reached the maximum effect for 4 ~ 6h. Different from other diuretics, this product has high lipid solubility. After oral absorption, the plasma concentration of liver and kidney is the highest, while the concentration of heart, lung, muscle and fat is lower. This product is mainly excreted from the kidney by metabolites and 5% prototype. Indapamide is suitable for mild and moderate primary hypertension, can also be used for congestive heart failure caused by water sodium retention, with renal failure are also applicable to the patients with high blood pressure, diabetes, hyperlipidemia, use antihypertensive effect is remarkable, and beta blockers used curative effect is better, because this drug has diuretic effect, can cause hypokalemia, can complement potassium at the same time.

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